NUAK1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016245
Fusion event
HBV-NUAK1 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2646
End
2681
Orient
+
Integrated sequence
CAGGTTTTATCCAAAGGTTACCAAATATTTACCATT
Host Sequence
Chromosome
chr12
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
106460935/106067157 (Hg38)
End
106460970/106067192 (Hg38)
Orient
-
Location type
Intronic
Target gene
NUAK1
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-1-3p ; hsa-mir-93-5p ; hsa-mir-26a-5p ; hsa-mir-211-5p ; hsa-mir-770-5p ; hsa-mir-556-3p
Nearest miRNA
hsa-let-7i/Upstream/1475441; hsa-mir-1178/Downstream/2568618;
Nearest TSS
ENST00000382841/Upstream/8903; ENST00000548901/Downstream/16841;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/735883, chr12-CpG: 176/Downstream/71136
Nearby gene
C12orf75(-695639) ; CKAP4(+170723) ;
Nearest cancer related gene
NUAK1(TSG, No orient, 0)
Upstream sequence
aagtcttctgcttctttacttctgtgcagttgttctatccattattcagaggggaatattaaagtatccaactattattagtaaaactatgtttttcttc
Downstream sequence
GAGTATTTGCTGCTGTGTTTCAAGATGCCCTTCCTCCGGCAGGAGAGGCTGTGGGAGGTTACCCTGGCTGGGTCCGGGGGGCTGGGGGAGGGGATGCTGC
Target sequence
CAGGGCTGACCAGGGCTGGGTCCATGGTGCCCGCT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate