SPG11 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016258
Fusion event
HBV-SPG11 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1037
End
1072
Orient
+
Integrated sequence
TGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGT
Host Sequence
Chromosome
chr15
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
44884617/44592419 (Hg38)
End
44884652/44592454 (Hg38)
Orient
+
Location type
Intronic
Target gene
SPG11
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-22-3p
Nearest miRNA
hsa-mir-1233-1/Upstream/798660; hsa-mir-10393/Downstream/125390;
Nearest TSS
ENST00000557528/Upstream/1482; ENST00000632133/Downstream/2819;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/54668, chr15-CpG: 63/Downstream/70639
Nearby gene
EIF3J(-29651) ; PATL2(+73277) ;
Upstream sequence
CTGGGTGATGGTTACATGGCAATCACTTTGTGATATGCCATCTGTGATAAACTACTGTGACATGTTGTTCTTTTCTTTCAAATATGCTTCTGTAATAGAT
Downstream sequence
GAAAAAAATTACAAAATTTTGAACTTAATATTTTTTCAATGAATAATGCCAAATAAGAGAATGTTAAAAATGCTATTAATAAggcagggcacagtggctc
Target sequence
CCAGTAGTAACGGGGAATCCTTTGACAAAGAGTTT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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