Basic Information
VIS ID
TVIS10016265
Fusion event
HBV-C16orf47 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
42
End
77
Orient
-
Integrated sequence
AGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCA
Host Sequence
Chromosome
chr16
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
73226792/73192893 (Hg38)
End
73226827/73192928 (Hg38)
Orient
+
Location type
Intronic
Target gene
C16orf47
Nearest miRNA
hsa-mir-1225/Upstream/3162471; hsa-mir-11401/Downstream/3676008;
Nearest TSS
ENST00000527434/Upstream/48446; ENST00000577171/Downstream/39127;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/126001, chr16-CpG: 74/Downstream/1103707
Upstream sequence
CAGGATGCCCCTCTCCTGCTCTCCTCCCTCCCTGGCTTCTCCCCATCTTGCTGCCCTAGGTtctgtctgcccatcccctggatgatctcatccactcatt
Downstream sequence
ACTATGCTGctaagcctcagtttccctgtctgtgaaactggaggaataatagccacctcattgggttgttttgaggattaaatgaaataatggaaggaaa
Target sequence
TGGACACAAGTGGGTCTAAAGTCTGCAACTTCCTA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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