Basic Information
VIS ID
TVIS10016266
Fusion event
HBV-chr16 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
985
End
1020
Orient
+
Integrated sequence
AGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGC
Host Sequence
Chromosome
chr16
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
80117326/80083429 (Hg38)
End
80117361/80083464 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA16D
Target gene
LOC105371357 ; LOC105371358
Nearest miRNA
hsa-mir-1225/Upstream/3214410; hsa-mir-11401/Downstream/1301554;
Nearest TSS
ENST00000527434/Upstream/17580; ENST00000566030/Downstream/95665;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/481789, chr16-CpG: 42/Downstream/457380
Nearby gene
MAF(-482704) ; DYNLRB2(+457527) ;
Upstream sequence
ctcatcGCACAAATGGGGTCATTCATTTCCTTCCCTCTCCTTTTTCTTGTCTCCTTGGGCGATCGACTGGCCCAACAGGGAAGAGCAAATGGTGGGGAGC
Downstream sequence
GGATTATGAGTGAGTTGAAAAATTCAGGGAGGTTTTTGACACATTCTCCAACCAAGAAAGATaaagtatgtgggctctggattcaaacaggcctagattt
Target sequence
ttgttccatgaattcccctcCACCACACCTCCCTT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate