Basic Information
VIS ID
TVIS10016269
Fusion event
HBV-chr18 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
630
End
665
Orient
-
Integrated sequence
GGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTC
Host Sequence
Chromosome
chr18
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
13834552/13834553 (Hg38)
End
13834587/13834588 (Hg38)
Orient
+
Nearest miRNA
hsa-mir-3976/Upstream/223353; hsa-mir-1-2/Downstream/995578;
Nearest TSS
ENST00000575820/Upstream/9009; ENST00000591211/Downstream/80952;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/8029, chr18-CpG: 37/Downstream/33945
Nearby gene
MC5R(-7691) ;
Upstream sequence
AGGAAACTCAAAGGAGAAAGAGGCCTTTTTAAAAATCTATTTCCTTTGGGCCAAGGGGGCCAATCTGTGTCTGAGAAAGGCTGACCCTGCGGCGTCCTTG
Downstream sequence
TTAATTAAGCCTTATGAATGTTGAGTAAGGTTTGGGAACACAGGCTCCTTCTACTTCATTTAGCCTTGGGTTAACAAATGGCAAATGAGCGGATGTCTCA
Target sequence
atcCTGCGTTTTCTGACCCCTGTCTGAATGTCAGT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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