PRKCE _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016273
Fusion event
HBV-PRKCE integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1566
End
1601
Orient
-
Integrated sequence
ATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGC
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
46121559/45894420 (Hg38)
End
46121594/45894455 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
PRKCE
miRNAs that regulate target gene
hsa-mir-205-5p ; hsa-mir-1-3p ; hsa-mir-31-5p ; hsa-mir-96-5p ; hsa-mir-21-5p ; hsa-mir-342-3p ; hsa-mir-107 ; hsa-mir-146a-5p
Nearest miRNA
hsa-mir-1301/Upstream/10422934; hsa-mir-10b/Downstream/1483220;
Nearest TSS
ENST00000437798/Upstream/196438; ENST00000489067/Downstream/83640;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/241874, chr2-CpG: 289/Downstream/402195
Nearest cancer related gene
PRKCE(TSG, No orient, 0)
Upstream sequence
cttgggtaaatcacttaatctcagtttccttgtctatagaatgggttggatacttacatgtaccttgtaggtgggtaataatgaatgggaaagtacctaa
Downstream sequence
GTCATTTAGTTAACACTGAAGAATCTCTTAAGATGACACATCTTTGCAGGGTGTGAAGGAAGgtgaccttgggcaagttacttagcttacctgaaatgtg
Target sequence
GAGGGCAAACTAGATGGAATGCTCTGGGGAGTAGC
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate