Basic Information
VIS ID
TVIS10016275
Fusion event
HBV-chr2 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
135
End
539
Orient
+
Integrated sequence
ATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGG
Host Sequence
Chromosome
chr2
Cytoband
p12
Reference genome
GRCh37/hg19
Start
81097601/80870476 (Hg38)
End
81097953/80870828 (Hg38)
Orient
+
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1285-2/Upstream/1003893; hsa-mir-10b/Downstream/4912772;
Nearest TSS
ENST00000437798/Upstream/286; ENST00000448431/Downstream/596118;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/547803, chr2-CpG: 93/Downstream/323252
Nearby gene
CTNNA2(-221648) ; DHFRP3(+1986290) ;
Nearest cancer related gene
CTNNA2(TSG, -221648) ;
Upstream sequence
AAGGTCACCACCAGCCCAGTATGGAATTCAGCATGTAGAAGACTTAATTTGGATTTTTTTTGGTAATTAATTTATCTTCTCTTGTGGACTAAATTATTTT
Downstream sequence
GGACAGGGCTCCCAGTCTTTAAatcttgggtccacaatcagcaatttacttcagcaccaggttccccatctatatataataatacagctgaaaatgtttg
Target sequence
aaGTGGAATTGAGTTCCTTGGCTTGTTTATTGGTGTTGAAGAGAGCAGCAATTCCTATAAAACTTTAATTCTAAGAACAAAAGGCATCTCTGGCACTTTCTCTCTATCCCTGTATATTTCTATCCCATCCACAACCAGACCTCCCCATAAGAAATCCTCTCCTTTGCCGTGGGTTTCTGAGGGCTGATTCAGCCTTCTCCCTACATGAGGGCTTTAAGGTATTGGTTTCCAACCTCAGGTCATGGTTAATCCTCT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate