VWA3B _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016276
Fusion event
HBV-VWA3B integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1804
End
1826
Orient
+
Integrated sequence
GCACCAGCACCATGCAACTTTTT
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
98769618/98153155 (Hg38)
End
98769878/98153415 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2A
Target gene
VWA3B
Nearest miRNA
hsa-mir-1285-2/Upstream/1354802; hsa-mir-10b/Downstream/3156035;
Nearest TSS
ENST00000437798/Upstream/25002; ENST00000466852/Downstream/38855;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/65729, chr2-CpG: 114/Downstream/192995
Upstream sequence
ATTTATCTTCTCTTGTGGACTAAATTATTTTGAGGCAACACAGTTTTAAAAATGTAAAATTGTTAGCTCTCAGAAAATTCAGGAAAATGAAACCCCTAGA
Downstream sequence
AACTGTGCTTTTTGTGTTGGTGGAGAAAAATGCATGAACTAAGACTAAATATTATGAAACTGAGTTTTATTTACATAAGGACACATTCAGGCTGCTATGC
Target sequence
CTCATTGTTTAGAACTATCAAATAGCACTCGCTCTGCTCACTATCATATTTTGCTTATGGGACAAGAGAAAGGCTGCAATGAATGAATCAAAAGAATAAATATTAGGTAATAGCAAAAGGTAATGTTTTTCTGAGAGTAGTTTTGTTTGTGTCCAGTACTCCTGGCAAATGTCCTTAGAACAGCTACTATACTCTACCAGTATTATTCTTAAGTCCAAAAATATTGTAGCTGTAAAAATGTGGGTGATTCTACCT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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