VWA3B _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016277
Fusion event
HBV-VWA3B integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1478
End
1543
Orient
-
Integrated sequence
GGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCG
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
98769649/98153186 (Hg38)
End
98769883/98153420 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2A
Target gene
VWA3B
Nearest miRNA
hsa-mir-1285-2/Upstream/1354833; hsa-mir-10b/Downstream/3156030;
Nearest TSS
ENST00000437798/Upstream/25033; ENST00000466852/Downstream/38850;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/65760, chr2-CpG: 114/Downstream/192990
Upstream sequence
TGCTTGTTAGCATCTTATCAGTGTTTCACAAAAATCCAGGAAATAACTTGCTTTGAGTCTCTTCCATATTTTCAAGATCCACTGTTGTTGCTTTTCCCTG
Downstream sequence
TGCTTTTTGTGTTGGTGGAGAAAAATGCATGAACTAAGACTAAATATTATGAAACTGAGTTTTATTTACATAAGGACACATTCAGGCTGCTATGCTTAAA
Target sequence
CTCTGCTCACTATCATATTTTGCTTATGGGACAAGAGAAAGGCTGCAATGAATGAATCAAAAGAATAAATATTAGGTAATAGCAAAAGGTAATGTTTTTCTGAGAGTAGTTTTGTTTGTGTCCAGTACTCCTGGCAAATGTCCTTAGAACAGCTACTATACTCTACCAGTATTATTCTTAAGTCCAAAAATATTGTAGCTGTAAAAATGTGGGTGATTCTACCTTCAGAAACTG
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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