Basic Information
VIS ID
TVIS10016280
Fusion event
HBV-chr2 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1577
End
1612
Orient
+
Integrated sequence
CGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGG
Host Sequence
Chromosome
chr2
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
118268651/117511075 (Hg38)
End
118268686/117511110 (Hg38)
Orient
+
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1285-2/Upstream/3789707; hsa-mir-10b/Downstream/9912427;
Nearest TSS
ENST00000437798/Upstream/1696412; ENST00000489933/Downstream/293064;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/2347886, chr2-CpG: 48/Downstream/303426
Upstream sequence
AGGGGAAATTTCCATCAGGACTGCTGATATTTCTTTATCTCCCCATTTCCTGAGGAGGCTGGACAAATCTGAAATTCAGAAAGTGAGTCATCTTCCTGCA
Downstream sequence
CATGGAAGCTGCTAAGTGAATGTGAAGAAGGCCTTGGGTGTCAGGACTTAACAGCCAGGTGGATTGCGCTGCTGCAGATTCATCCACATGCCTGATGAAT
Target sequence
TCTGGACATATGAATTTTAATTTTTCAACGTCCCT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate