Basic Information
VIS ID
TVIS10016284
Fusion event
HBV-chr2 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2334
End
2369
Orient
-
Integrated sequence
GAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCT
Host Sequence
Chromosome
chr2
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
147415573/146658005 (Hg38)
End
147415608/146658040 (Hg38)
Orient
+
Fragile sites / regions
FRA2S ; FRA2K
Nearest miRNA
hsa-mir-128-1/Upstream/6071320; hsa-mir-10b/Downstream/2672238;
Nearest TSS
ENST00000437798/Upstream/742915; ENST00000450667/Downstream/179709;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/70194, chr2-CpG: 79/Downstream/1185671
Upstream sequence
TATATTTTACAGAGTAAAGAAGTAGGGAGCTGGAATAATTCTAGGCAGGAGGGATTCATTTTAGCAGTCAGTGAATTGTGATACTATAGTTGGGAAGTAC
Downstream sequence
AAAGTCACTGCCTAAAAAGAGAAGAAAGGAATACAGATTTTACCTGGTTTAAAATTCTTATTTCCACTGACCAATTAATCAAAACATATTGTCTTTAGTC
Target sequence
GATTCTTTAAAAAATGAATGATGTTAGACAACTAT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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