Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016291
Fusion event
HBV-PLCL1 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
3134
End
3169
Orient
-
Integrated sequence
CCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAG
Host Sequence
Chromosome
chr2
Cytoband
q33.1
Reference genome
End
198791251/197926527 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
hsa-mir-599 ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-6844 ; hsa-mir-4775 ; hsa-mir-4778-3p ; hsa-mir-4735-5p ; hsa-mir-3692-3p ; hsa-mir-1236-3p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-3064-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-130b-5p ; hsa-mir-4727-5p ; hsa-mir-6817-5p ; hsa-mir-4769-3p ; hsa-mir-140-3p ; hsa-mir-6728-3p ; hsa-mir-552-5p ; hsa-mir-302c-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6873-3p ; hsa-mir-186-3p ; hsa-mir-4714-3p ; hsa-mir-4272 ; hsa-mir-3149 ; hsa-mir-374a-3p ; hsa-mir-361-5p ; hsa-mir-4328 ; hsa-mir-5094 ; hsa-mir-6768-5p
Nearest miRNA
hsa-mir-10b/Upstream/8793381; hsa-mir-1244-1/Downstream/8856707;
Nearest CpG islands
Upstream sequence
GAATGACTGAATGGTGGCTCACCAAAAATTCCACCAAAATAACCTATTAAAgataaagcatggctgacttaattgcttagtttggtaaaaaagatcactc
Downstream sequence
AAAAATTTGTCTCTTTAACTTTGTATTCATTTGATGTTGCCTTTTCTAACCGTGaccataaataaaaacccactatcacatggcacaaacataaataaga
Target sequence
CTTTCAAACTCAAATTATAATTTACGTGATATTTA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.