Basic Information
VIS ID
TVIS10016294
Fusion event
HBV-chr2 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2078
End
2113
Orient
+
Integrated sequence
TCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTG
Host Sequence
Chromosome
chr2
Cytoband
q33.2
Reference genome
GRCh37/hg19
Start
204689662/203824939 (Hg38)
End
204689697/203824974 (Hg38)
Orient
+
Fragile sites / regions
FRA2I
Nearest miRNA
hsa-mir-10b/Upstream/14691828; hsa-mir-1244-1/Downstream/2958260;
Nearest TSS
ENST00000437798/Upstream/118391; ENST00000295854/Downstream/42812;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/289493, chr2-CpG: 83/Downstream/720242
Nearby gene
CD28(-87140) ; CTLA4(+42811) ;
Upstream sequence
GGAGTCCAGCTAGAGTGGGCAGCACGGAGCCAGCAAGTGTTTGTCCTGCCAGCCACAGGCTTCTGCTCAGCCTTGCCTCGCCTCCTTGCTGGGAGAGTGG
Downstream sequence
tgaagccttaatttccaatctgactgtatatggagttaaggaactttaagaaggcaattaaagttaaatgaagttacaagggtaggtccctaatctgata
Target sequence
ATGGCCTGCCTCCCCCAcctcccaaattcatgtgt
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate