Fusion event
HBV-FN1 integration
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
CATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTACTCTCT
End
216297998/215433275 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10b/Upstream/1675060; hsa-mir-1244-1/Downstream/2467238;
Upstream sequence
TATTCCCTTAGAACCTTTCCATGTTATCCTTTATCTTTATGCAATGTTTCCCATATGTCAGCCATTCATGGCCATTCACCATCCCATTTTTTGTTATGAG
Downstream sequence
AATTCATATTTGATATTTTGGCATCATTTTACACAATCTCTTCCTTACTTGCGATGGTACAGCTTATTCTCCCTCGCCCAGCCCCGATGCAGGTACAGTC
Target sequence
AAAGTTCGGAATATCCAGTCATGGATAACAGAAAATGACAGTGATGGTAACAGAGA
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.