Basic Information
VIS ID
TVIS10016304
Fusion event
HBV-LINC00607 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1511
End
1700
Orient
-
Integrated sequence
CGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGA
Host Sequence
Chromosome
chr2
Cytoband
q35
Reference genome
GRCh37/hg19
Start
216488666/215623943 (Hg38)
End
216488863/215624140 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC00607
Nearest miRNA
hsa-mir-10b/Upstream/1865784; hsa-mir-1244-1/Downstream/2276373;
Nearest TSS
ENST00000437798/Upstream/2590; ENST00000428487/Downstream/53884;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/187806, chr2-CpG: 51/Downstream/389036
Nearby gene
FN1(-187875) ; MREG(+318647) ;
Upstream sequence
gcactgcagcctggcgacagagccagactcttatctcaaaacaaacaaacaaacaaacaaaaaacaCCTGTTCTACAAAGCAAGGTGGTGGTTTTACAGT
Downstream sequence
ACCAGCAGTTTCTTCAAGTTCATGGCATTGCACGTGGAGTGGCAGGACTTATGGAGCGGTTTTGATGCGATATGATACTCTGCCTTAAAACAACTCTAGA
Target sequence
ACTGTCCAAACAAACTTCCCAGATAAAAGTTCTAAGTTTAAGCTTTGGAAATGTGTTGCTGTGGCCACTTATACTCAAAGAAAAGAGAGGACGAGGGAGGGGGAAGGAAGGAAAGTACTCTGGATCCAAAAGTTCAGGGTAGTTTTACAACACTTTGACAACACTTACTTGCCTGGTCACAGCATTTGCTTTCTCTT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate