KIF1A _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016305
Fusion event
HBV-KIF1A integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
3
End
38
Orient
+
Integrated sequence
TCCACAACCTTCCACCAAACTCTGCAAGATCCCAGA
Host Sequence
Chromosome
chr2
Cytoband
q37.3
Reference genome
GRCh37/hg19
Start
241706698/240767281 (Hg38)
End
241706733/240767316 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2J
Target gene
KIF1A
miRNAs that regulate target gene
hsa-mir-423-5p ; hsa-mir-652-3p ; hsa-mir-423-3p ; hsa-mir-149-5p ; hsa-mir-9-5p ; hsa-mir-92a-3p ; hsa-mir-17-5p ; hsa-mir-15a-5p ; hsa-mir-493-3p
Nearest miRNA
hsa-mir-10b/Upstream/311192; hsa-mir-3133/Downstream/710589;
Nearest TSS
ENST00000437798/Upstream/18563; ENST00000472436/Downstream/3978;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/65339, chr2-CpG: 88/Downstream/10306
Upstream sequence
aacaaacaaacaaacaaacaaaaaacaCCTGTTCTACAAAGCAAGGTGGTGGTTTTACAGTGAAAGTTGAAAAGTAGCTGAACTGCTGGAATTGACCATA
Downstream sequence
TCCTCGTTCAGGTTGACGAGGTGTGGTGTCTGCAGGGAGACAGGAGGATCATCTCTCTTGCAGAGGGGCAGGAGCCTGATGCTGGCCACACCCCCCTCCA
Target sequence
TGATGTAGTAGAGCAGGCACTCAGACATCAGCGGG
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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