Basic Information
VIS ID
TVIS10016306
Fusion event
HBV-chr20 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
316
End
569
Orient
+
Integrated sequence
AGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGC
Host Sequence
Chromosome
chr20
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
11725419/11744771 (Hg38)
End
11725594/11744946 (Hg38)
Orient
+
Fragile sites / regions
FRA20B
Nearest miRNA
hsa-mir-103a-2/Upstream/1095076; hsa-mir-1-1/Downstream/6725669;
Nearest TSS
ENST00000382410/Upstream/57448; ENST00000450368/Downstream/65480;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/57422, chr20-CpG: 126/Downstream/145780
Nearby gene
JAG1(-1070900) ; BTBD3(+145882) ;
Upstream sequence
ctgcctcccacactgctctgtgggctccctaagacaaaccgtctgtccgtcttacttatcgcttattctcaagactctaggacaggCCAAGGGAAGAAAT
Downstream sequence
CTAATTTTACATTAAAATAGATGTTGGGTTTTATGCTCCTGCAAGGAGAAAACCTGAATTCACAAGCAGAGCCATATGACAGGAGATACATTCAAAATAT
Target sequence
AAATCATAGCATGATCAATAAAACATATAGATTGCATATTAAATACAAATCTGCTGATAATATTGACTATGCAACTATGATCTTTTTCCTGGAGGGTGAAAAAGGTTCAGAGTGCATGCTATCCAATATAATCATGTGTTTGGTATCATATGCTTCTTATGCCTTCAACAAATCT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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