Basic Information
VIS ID
TVIS10016309
Fusion event
HBV-chr20 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1317
End
1621
Orient
-
Integrated sequence
CAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGC
Host Sequence
Chromosome
chr20
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
62328851/63697498 (Hg38)
End
62329121/63697768 (Hg38)
Orient
+
Location type
Intronic
Target gene
RTEL1-TNFRSF6B ; TNFRSF6B
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-132-3p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-1-1/Upstream/410632; hsa-mir-1914/Downstream/221681;
Nearest TSS
ENST00000382410/Upstream/847; ENST00000431125/Downstream/2533;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/293, chr20-CpG: 180/Downstream/9539
Upstream sequence
ATTTATTTTTCAATTAGTAAGTTTTCTCAACAGGCTGTTCTATATACCAAGAATTTTATTTCAGTGGGAAAGAGGCCATAGTTATTTTTATTTCATTATC
Downstream sequence
AATCTCCTAACTGCCCGAGGGGAAGGTGGCTGGCTCCTCTGACACGGGGAAACCGAGGCCTGATGGTAACTCTCCTAACTGCCTGAGAGGAAGGTGGCTG
Target sequence
TCCCCCTCAGCACCAGGGTACCAGGTGAGCCAGAGGCCTGAGGGGGCAGCACACTGCAGGCCAGGCCCACTTGTGCCCTCACTCCTGCCCCTGCACGTGCATCTAGCCTGAGGCATGCCAGCTGGCTCTGGGAAGGGGCCACAGTGGATTTGAGGGGTCAGGGGTCCCTCCACTAGATCCCCACCAAGTCTGCCCTCTCAGGGGTGGCTGAGAATTTGGATCTGAGCCAGGGCACAGCCTCCCCTGGGGAGCTCT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate