TMPRSS6 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016310
Fusion event
HBV-TMPRSS6 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1597
End
1632
Orient
-
Integrated sequence
TCTGCACGTCGCATGGAGACCACCGTGAACGCCCAC
Host Sequence
Chromosome
chr22
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
37505235/37109195 (Hg38)
End
37505270/37109230 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
TMPRSS6
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-4322 ; hsa-mir-4296 ; hsa-mir-4265 ; hsa-mir-4417 ; hsa-mir-609 ; hsa-mir-4455 ; hsa-mir-6772-5p ; hsa-mir-2861 ; hsa-mir-661 ; hsa-mir-4518 ; hsa-mir-1266-5p ; hsa-mir-6742-3p ; hsa-mir-6798-5p
Nearest miRNA
hsa-mir-1286/Upstream/822288; hsa-let-7a-3/Downstream/735042;
Nearest TSS
ENST00000624155/Upstream/5539; ENST00000419128/Downstream/179;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/11061, chr22-CpG: 33/Downstream/72962
Nearest cancer related gene
TMPRSS6(TSG, No orient, 0)
Upstream sequence
CATAGGTGCAATGTGGGGCTCCGGGCCTGTCTCCTACACCAGAAGGCCCAGGTGGGGTACCGGGTGTGGAGGGGGCAGCATGTCCAGTCCTGCGAGGCAG
Downstream sequence
CACCTGAATCCCAGGCCACCAACCACCCAGCACTGATGCTGTGCCTGTCCACACACCTGGTGTCACCCTGCGTGGTCCCTCCCCTCCCCAGCTCTGTGGG
Target sequence
GGGTAGGGTGGCCTCTCCCTTCCTCCTGTCCCTGC
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate