Basic Information
VIS ID
TVIS10016313
Fusion event
HBV-LOC105377110 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
967
End
1002
Orient
-
Integrated sequence
CAGGCCTATTGATTGGAAAGTATGTCAACGAATTGT
Host Sequence
Chromosome
chr3
Cytoband
p14.2
Reference genome
GRCh37/hg19
Start
59518543/59532817 (Hg38)
End
59518578/59532852 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3B
Target gene
LOC105377110
Nearest miRNA
hsa-let-7g/Upstream/3680223; hsa-mir-12124/Downstream/1084953;
Nearest TSS
ENST00000440867/Upstream/22139; ENST00000475527/Downstream/481298;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/482599, chr3-CpG: 48/Downstream/1718080
Upstream sequence
ACATCTGCAGGTCACCCCACAGATTGCTAAATCAGAATCTCAATGAATTTACAAAAATCTCCTTTTTCAAAAATAATATATTTTGACCTGCAAATCCTTA
Downstream sequence
ATGAGTGTATGTAGCAAATTTTTCCTATTAGTAAGCATCACCTGACAGATGTTCAAAGATGGTGGTTCTATAGGTCTGCTTCTGCTGAGGAGGCATGGTT
Target sequence
AATATCAAATCAAATGAGCAAGAATGTGGACAGCA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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