Basic Information
VIS ID
TVIS10016318
Fusion event
HBV-chr3 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
481
End
557
Orient
-
Integrated sequence
TAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTAT
Host Sequence
Chromosome
chr3
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
167139470/167421682 (Hg38)
End
167139700/167421912 (Hg38)
Orient
-
Nearest miRNA
hsa-let-7g/Upstream/3250126; hsa-mir-1224/Downstream/1129942;
Nearest TSS
ENST00000440867/Upstream/28886; ENST00000472941/Downstream/25093;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/41272, chr3-CpG: 37/Downstream/312676
Nearby gene
ZBBX(-41580) ; SERPINI2(+20057) ;
Nearest cancer related gene
SERPINI2(TSG, +20057) ;
Upstream sequence
GCTGTGCTCACAGGCCCTCTGAGCACACCCAGACTCCATTTCCCTCTTTCTCTCACTACCCTTAACATGTTTACACACGCCCCATGCCCAAATAATCTGG
Downstream sequence
CCAAAACAGCCCCCAAAATAGCAATGAAAATATAACTTTCTCAGATTAAAGTCCAATGCAGGTATGACTGATTCGTTTTAGCCAAAGCTGCATAGGGGCT
Target sequence
cagtctCTGGCTGGAtactgggtcagtattcacatggtgtgtttccaaattatcacaggcaaaaattttaccagatagctccacaactaaataagatttcctgccttctaacctgctatttctttgtttttgttcttgttatggctctccaacttcaaattatgccacatattttgcattgtgtatagaagcccctattgaaaataccaaATTACCATCCACTACTGTCA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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