VISDB Viral Integration Site DataBase

VIS ID

TVIS10016322

Fusion event

HBV-PPARGC1A integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Start

1410

Orient

-

Integrated sequence

TCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGC| |GCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTT

Chromosome

chr4

Cytoband

p15.2

Reference genome

Start

End

24234778/24233155 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-23a-3p ; hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-421 ; hsa-mir-425-3p ; hsa-mir-378a-5p ; hsa-let-7b-5p ; hsa-mir-130b-3p ; hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-190a-3p ; hsa-mir-4775 ; hsa-mir-3124-3p ; hsa-mir-5011-5p ; hsa-mir-32-3p ; hsa-mir-5585-3p ; hsa-mir-3941 ; hsa-mir-8064 ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-485-3p ; hsa-mir-485-5p ; hsa-mir-130a-3p ; hsa-mir-4311 ; hsa-mir-4524a-3p ; hsa-mir-4524b-3p ; hsa-mir-4668-5p

Nearest miRNA

hsa-mir-12113/Upstream/1717770; hsa-mir-1243/Downstream/287037;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/1716730, chr4-CpG: 266/Downstream/236922

Nearby gene

PPARGC1A(-343078) ; MIR573(+287036) ;

Upstream sequence

AGCTTGACAGTTCAGCTTCGACTTAGTACTTGAATAGTTTTCAAAAAAATGTTTTTGTAGTTGAATTTAATGAGAAATCATCAGAAAGGTTATTGAGAAC

Downstream sequence

AAGTCTCACTTAGAAGCAGATGCAAATAAAATGAGATTTGAGAATTTCCTCCACAATTTAAAACAAAGAAATAAAAATATTTTAACAAATCACCCAATAG