Basic Information
VIS ID
TVIS10016325
Fusion event
HBV-LOC102723846 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1605
End
1640
Orient
-
Integrated sequence
TCGCATGGAGACCACCGTGAACGCCCACCAAATATT
Host Sequence
Chromosome
chr4
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
32228702/32227080 (Hg38)
End
32228737/32227115 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
LOC102723846
Nearest miRNA
hsa-mir-12113/Upstream/3407412; hsa-mir-1243/Downstream/4199251;
Nearest TSS
ENST00000502981/Upstream/229683; ENST00000515181/Downstream/123923;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1503860, chr4-CpG: 100/Downstream/4016894
Upstream sequence
CTATACTTGATTAATAACTCATCAAGGATAAAATAGTATAATACATAGGCCCAGCAACTCTAACAAGTGACTGGCCtttttttttttttttttttttttt
Downstream sequence
GGAGTACATACATCCTTTTACTGTTTATTGAGCTTGTTACAAAGCCTTATAAAAATGGGAAAAGGTGATCTTATGAACATAAATACTTGCAAAAAATTAA
Target sequence
aggccgactaactccagagCTGAAAAGCCCATGTA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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