Basic Information
VIS ID
TVIS10016336
Fusion event
HBV-chr5 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2409
End
2540
Orient
+
Integrated sequence
TCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATC
Host Sequence
Chromosome
chr5
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
28325819/28325712 (Hg38)
End
28325891/28325784 (Hg38)
Orient
-
Fragile sites / regions
FRA5E
Nearest miRNA
hsa-mir-10397/Upstream/11169720; hsa-mir-103a-1/Downstream/3610318;
Nearest TSS
ENST00000502646/Upstream/38047; ENST00000602801/Downstream/483465;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/1655917, chr5-CpG: 76/Downstream/483509
Upstream sequence
CCAAGTGAGACATGAAAGGAGGATTTGAGCCGAATTATTTTTGTAGAAGCACAATGTGGGGCATTTGCTTAAGGAGCAATACCAGACTCTCTGTGCCTTG
Downstream sequence
TTTCTTACGAAATCAACATAAAATTTATTTATAATGCTTTTTTCCAAAGTAATAAAAGAAAATTTAATTTCATGTAGCAAATATTTAAGTGGGAGATGAA
Target sequence
GAGAGGTTAACTAAATTTTTAAAATATGAAGGGAAACAAAAATAATATATTAGGCAGTTTATTATGTATCTT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate