Basic Information
VIS ID
TVIS10016338
Fusion event
HBV-chr5 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1562
End
1790
Orient
-
Integrated sequence
TCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCA
Host Sequence
Chromosome
chr5
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
67420522/68124694 (Hg38)
End
67420767/68124939 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-10397/Upstream/8420991; hsa-mir-103a-1/Downstream/4044528;
Nearest TSS
ENST00000502646/Upstream/222094; ENST00000520762/Downstream/64937;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/960927, chr5-CpG: 159/Downstream/90105
Nearby gene
CD180(-927905) ; PIK3R1(+101939) ;
Nearest cancer related gene
PIK3R1(OG, +101939) ;
Upstream sequence
ATTCCCACTTGGCTTCTCATTTTATTGTCACAACAAGCCCTGtgagtttcaggggattaaatgagctgcataagcaccagctgagtgctagtaagtggca
Downstream sequence
caaaaaagagcctgagtagccgaggcattcctaagcaaaaagaacaaagctgaaggcaacacactacctgatttggctgtgtccccacccaaatctcatc
Target sequence
caggaatacagctaatgagggaggtgaaaaggctctgcaaggtgaactacaaaacactgctcaaagaaatcagagatgacccaaacaattggaaaaacattccatgctcatggataggaagaatcaatattattaaaatgaccatactacccaaagcaatttatagattcaatgctattcataatgaactaccattgacattcttcacagaactagagaaaacaattttaaaattcttatgcaac
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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