Basic Information
VIS ID
TVIS10016339
Fusion event
HBV-chr5 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2240
End
2275
Orient
+
Integrated sequence
AACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTG
Host Sequence
Chromosome
chr5
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
90963090/91667273 (Hg38)
End
90963125/91667308 (Hg38)
Orient
+
Nearest miRNA
hsa-mir-10397/Upstream/1650553; hsa-mir-103a-1/Downstream/1953388;
Nearest TSS
ENST00000502646/Upstream/283914; ENST00000511323/Downstream/415289;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/286160, chr5-CpG: 183/Downstream/1903225
Upstream sequence
tcccttagaactttcctttgtggggtgggttctgggagtttcacagattgttaggttttggtaaagcgtcatggaagtctgcatgtacaagatttctgac
Downstream sequence
AGTTTAGCCTCAAGTTTTGGGCTTTTTATTAAACTTTGTTCAAATGAAAATCTCTTTCCTTTCGGCTATTAGGTTTATGCTTGAAACATTACTGTATCTG
Target sequence
ATTTTGCTCTGTTATCAGCCAGTTTCACAGTTTAA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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