Basic Information
VIS ID
TVIS10016343
Fusion event
HBV-chr5 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
844
End
879
Orient
-
Integrated sequence
CAAAACAAAGAGATGGGGTTACTCTCTAAATTTTAT
Host Sequence
Chromosome
chr5
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
149811327/150431764 (Hg38)
End
149811362/150431799 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-10397/Upstream/698874; hsa-mir-103a-1/Downstream/1090288;
Nearest TSS
ENST00000502646/Upstream/18835; ENST00000518346/Downstream/15138;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/73877, chr5-CpG: 46/Downstream/17781
Upstream sequence
CCACTAGAACATGACAGGTCCTGAAATTGATGCATCAGCCCCAGGACCTTTATGGGCAGGCAGTGGGTTCAGGCCTGCCAGGCACCGTGACAAATAAGTC
Downstream sequence
agagcacttcctctcaatccccatgtcatactgcttcccGCAGGCTTCTTACTTCGAGCAGTCTTAGGATCAGGTCACCTGCAATCTCTGTTCCCAAGGG
Target sequence
aagccacgatttgaagccaggtctgagctgtctcc
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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