Basic Information
VIS ID
TVIS10016348
Fusion event
HBV-TENM2 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1470
End
1505
Orient
+
Integrated sequence
GTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGC
Host Sequence
Chromosome
chr5
Cytoband
q34
Reference genome
GRCh37/hg19
Start
167423090/167996085 (Hg38)
End
167423125/167996120 (Hg38)
Orient
-
Location type
Intronic
Target gene
TENM2
Nearest miRNA
hsa-mir-10397/Upstream/7510635; hsa-mir-103a-1/Downstream/169725;
Nearest TSS
ENST00000502646/Upstream/28999; ENST00000521126/Downstream/166574;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/137223, chr5-CpG: 36/Downstream/266102
Upstream sequence
TTTTTCCCACTTTATTTTATGATGTGCAGCATCATAACATCACACTAACCTAACCCACATTTCAAAAAAATCACACGAATGTGGCCTAACCTAtatttct
Downstream sequence
GAAGACTTTCCAGAAATGAGCAGTTTGGACATTGCTCGGCCCCCTGACAAGTTCTTCCATAGATCCAGGCCCGTGGGCGGGTGTAAAAGCAGAATGCCAG
Target sequence
AAATTATCATCCTTGCGTGTTCAAACCCGAAGAAA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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