TTBK1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016350
Fusion event
HBV-TTBK1 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1513
End
1548
Orient
-
Integrated sequence
ACCGACCACGGGGCGCACCTCTCTTTACGCGGACTC
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
43254922/43287184 (Hg38)
End
43254957/43287219 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
TTBK1
Nearest miRNA
hsa-mir-10398/Upstream/1553574; hsa-mir-10524/Downstream/147323;
Nearest TSS
ENST00000381078/Upstream/39195; ENST00000480882/Downstream/8475;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1446, chr6-CpG: 24/Downstream/21462
Upstream sequence
ggccattattctaagtgaagtaactcagaaatagaaaaccaaataccctatgttctcacttataagtgggagctaagctatgagaatgcaaaaacatata
Downstream sequence
CCCTCTACTGCCCTCTGGGTCCAGCAGAGGGAGTGGAGGAAGGGCCACTGCCTCCCACCTAGAGCTTCTCCGAATGACAATCAGCTCGTGCCAGGTGGGG
Target sequence
AGAGCCCTCCTTGTCAACTTGAGGCCCTCCCAAGG
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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