Basic Information
VIS ID
TVIS10016362
Fusion event
HBV-chr7 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1345
End
1380
Orient
+
Integrated sequence
TGTCCTATCCCGCAAATATACATCGTTTCCATGGCT
Host Sequence
Chromosome
chr7
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
88157113/88527798 (Hg38)
End
88157148/88527833 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-10525/Upstream/12612529; hsa-mir-10399/Downstream/3676182;
Nearest TSS
ENST00000635602/Upstream/220907; ENST00000444032/Downstream/182798;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/307519, chr7-CpG: 65/Downstream/231341
Upstream sequence
TTGATTACAAGGAGGAGTAAATGGTGAAGGAAAGAACCGCTTTTTCTGTCCTCATTCCCCTATAAAATTTACATTTTTCCCCCACTAAGAACAACAGTAA
Downstream sequence
TATTTTAATTATGGGGTAACTTTTTGATCCAAATATTTTTAATAACATCACAGTCATACAGTTTACTTTGAGTAAGTGAAGTCTGTTCTTAGCTGCTTTT
Target sequence
CATGGCAGCCTCAATTTCACAGAGACCCCTGAAAA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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