Basic Information
VIS ID
TVIS10016364
Fusion event
HBV-chr7 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1515
End
1769
Orient
-
Integrated sequence
CGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTT
Host Sequence
Chromosome
chr7
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
109658146/110018089 (Hg38)
End
109658392/110018335 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-10525/Upstream/7546558; hsa-mir-10399/Downstream/4635010;
Nearest TSS
ENST00000635602/Upstream/420923; ENST00000464835/Downstream/516419;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1447627, chr7-CpG: 68/Downstream/1543688
Nearby gene
EIF3IP1(-58031) ; IMMP2L(+644808) ;
Upstream sequence
AATCAGACTGGCAAATGTATCTACTCTAATTTGGCCGATTTTTCAGCAGGCATTCACTGATTTCTGGGCATAGTTGGACAGCTCCCTTTACAGAAGGAAA
Downstream sequence
TAGAATAAAATAGATATAAATTATTGTTTGGAGAATATTCCCTCAATATTACTCTTGAGGGAAATATACTTGGTCTTGAATCTTGTATTAGTAACGTGAC
Target sequence
tatggcTTGTATTTTATTAGTGattatttaatgttatttaattaattatttGGAAATATTACTTTTCCAAGATAAGTGATCAGCCAAGTCAACTGATTTCAAGACCCTTACCCTTCCCAAGCTCCTATCAGTCTTTCTCTGGGAAGATAAGTATACCCATAGATGTTTAGCTATTTTACTGCCTACCTCTTCCTTCCAATACAATAATTTAAAGTTTATCACAGATATTATTTTACCTTTCAGAGA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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