Basic Information
VIS ID
TVIS10016370
Fusion event
HBV-MTERF3 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1860
End
2290
Orient
+
Integrated sequence
ACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGG
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
97262441/96250213 (Hg38)
End
97262833/96250605 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8B
Target gene
MTERF3
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p
Nearest miRNA
hsa-mir-12123/Upstream/1177217; hsa-mir-10400/Downstream/2143040;
Nearest TSS
ENST00000518652/Upstream/14579; ENST00000517557/Downstream/6465;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/88561, chr8-CpG: 111/Downstream/10782
Nearby gene
UQCRB(-14971) ; PTDSS1(+11333) ;
Upstream sequence
TTAAATAAACTGGACTCAAGAAACCTAATAAACTGGACCTCCATAGCTCGTATTGCTTTGTTGTTCTTGAAGAAATTTATCTACTAAATTTATATTTGTA
Downstream sequence
aggctgaggcagaagaagaagaagaagaagaagaagaagaagaagaagaagaagaagaagaagaagaagaagaagaaggaggaggaggagggggggaggg
Target sequence
TGCCAAGACAATCTCAAATGTCTAACAACAAAAATTGGCCAGACAAAAACTACAAAAACCACAAAAGATCATATCTTTAAGTGCACTCTCAGATAAGTTAGCTATTTGTTGATGGGTTTTTTTTTTTTTTAAGAAAAAAACGTATTCCAGTTTCTAAAGAGAAAGAGTTAATTACTGACTCAGTAATAAGTTGAAAACATAAAAATAATAATGGAgccaggcagggtggctcatgcctgtaaaatcccagcactt
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate