Fusion event
HBV-SYTL5 integration
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
GGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAA
End
37782089/37922836 (Hg38)
Nearest miRNA
hsa-mir-23c/Upstream/5281242; hsa-let-7f-2/Downstream/101059;
Upstream sequence
TCTGCCCAGGTGCAGGGAATATTTAGGGTCGTTGCATTGGAGGGAAATGGCTTCCTCTCAGATTCAGAGATCCCTAAAGTTGTAGAATCAGAACCTTAAA
Downstream sequence
CACTTAGTATCACATACATAACAGCTTTTCTTTCAGTCACCCCTGCTTCCTAGTAACTGGTTCTCCATGATActactacctctctctgacccatttcatc
Target sequence
GTCACAAGCTTAACGTGAATTTTCTCTTGTCCCCT
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.