Basic Information
VIS ID
TVIS10016385
Fusion event
HBV-chrX integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2034
End
2279
Orient
+
Integrated sequence
CCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATT
Host Sequence
Chromosome
chrX
Cytoband
q25
Reference genome
GRCh37/hg19
Start
126542361/127408379 (Hg38)
End
126542515/127408533 (Hg38)
Orient
+
Nearest miRNA
hsa-let-7f-2/Upstream/6037326; hsa-mir-105-1/Downstream/6760845;
Nearest TSS
ENST00000429181/Upstream/588615; ENST00000486673/Downstream/253997;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/827041, chrX-CpG: 50/Downstream/2114341
Nearby gene
PRR32(-586684) ; ACTRT1(+642488) ;
Upstream sequence
cccccagagattcttcaggaaggagtgaattaactaggcaaagggtggcctactctcaccatggaccccttgagtcctagctgcaggagactccatgacc
Downstream sequence
gtctccagatattattgtcttggagtctatctctctctttagttgtagaaatctttgctttgtatatctgagtgctccactgttgggtgtatacatatta
Target sequence
atgctgaggagaataatacattctgtctctgttgattgaaatgttctgtaaacatacgttaggtccatttgcattatagtgcagattctgtctgatgctttcttgttaatttttgtattaatgttctctccaatgctaagagtgagaacttgaa
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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