Basic Information
VIS ID
TVIS10016387
Fusion event
HBV-chrX integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1426
End
1795
Orient
-
Integrated sequence
TTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCA
Host Sequence
Chromosome
chrX
Cytoband
q25
Reference genome
GRCh37/hg19
Start
126560615/127426634 (Hg38)
End
126561054/127427073 (Hg38)
Orient
-
Nearest miRNA
hsa-let-7f-2/Upstream/6055581; hsa-mir-105-1/Downstream/6742305;
Nearest TSS
ENST00000429181/Upstream/606870; ENST00000486673/Downstream/235457;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/845296, chrX-CpG: 50/Downstream/2095801
Nearby gene
PRR32(-604965) ; ACTRT1(+624207) ;
Upstream sequence
CAGATCAAGGCATTGTAATACCTCTGCAGTATCCAGTTGAGAAGAAGTCCTCAGCTAGAAGTACACAAGGTACTACAGGTATGATTTCCTCTTAATTTTT
Downstream sequence
gaaatgcctattagacatcaagtaaaaatAGTGCTCCTTTCTTTCGTTCATGTTAACTACATATCTCTCTTCACCCAGAAGCTTATGTATTTTGTGTGAC
Target sequence
taattctgtgttgtatatgtcttgaggtgatcaagtgctctgtgcattgtaggatatttagcagaacttctgaccccccacccaccagaggccagtagcaaccctgcccctagttgtggcaactgaaaatgtctcccaacattgccaaatgtcctctggggcgaaaaatcaccttcagtagtcagaactgctggcccaggacaatagcagcataggcagtagtaacttactacattataaattattttaaaggca
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate