VISDB - VIS Detail

Expression analysis of TCGA samples

Basic Information

VIS ID

TVIS10016399

Fusion event

HBV-DCAF8 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Tumor

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2012

PubMed ID

22267523

Virus Sequence

Virus name

HBV

Reference genome

NC_003977

Start

2786

End

2821

Orient

-

Integrated sequence

GAGAAACAACACATAGCGCCTCATTTTGTGGGTCAC

Host Sequence

Chromosome

chr1

Cytoband

q23.2

Reference genome

GRCh37/hg19

Start

160207806/160238016 (Hg38)

End

160207841/160238051 (Hg38)

Orient

+

Location type

Intronic

Target gene

DCAF8

miRNAs that regulate target gene

hsa-mir-130b-3p ; hsa-mir-93-5p ; hsa-mir-26b-5p ; hsa-mir-21-5p ; hsa-mir-19b-3p ; hsa-mir-937-3p ; hsa-mir-877-3p ; hsa-mir-296-3p ; hsa-let-7g-5p ; hsa-let-7e-5p ; hsa-mir-4724-3p ; hsa-mir-218-5p ; hsa-mir-6728-5p ; hsa-mir-3978 ; hsa-mir-4709-3p ; hsa-mir-4769-5p ; hsa-mir-4654 ; hsa-mir-6778-5p ; hsa-mir-4648 ; hsa-mir-1233-5p ; hsa-mir-5187-5p ; hsa-mir-4735-3p ; hsa-mir-18b-5p ; hsa-mir-18a-5p ; hsa-mir-651-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-2681-5p ; hsa-mir-3691-3p ; hsa-mir-6813-3p ; hsa-mir-3200-3p ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-6071 ; hsa-mir-6854-3p ; hsa-mir-6828-3p ; hsa-mir-3692-5p ; hsa-mir-93-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-548p ; hsa-mir-6507-3p ; hsa-mir-6835-3p ; hsa-mir-4422 ; hsa-mir-20a-5p ; hsa-mir-106a-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-526b-3p ; hsa-mir-147a ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-6867-5p ; hsa-mir-644a ; hsa-mir-3911 ; hsa-mir-3177-5p ; hsa-mir-567 ; hsa-mir-3650 ; hsa-mir-511-3p

Nearest miRNA

hsa-mir-101-1/Upstream/337937; hsa-mir-1182/Downstream/989135;

Nearest TSS

ENST00000473358/Upstream/13488; ENST00000642063/Downstream/934;

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/32104, chr1-CpG: 53/Downstream/23914

Upstream sequence

tccttacatttcccagcacgcaaattgactaaatgtttaagtataacaaataaaatatgaaaaatacaggtgactatgtaaataaccttgggttggcaaa

Downstream sequence

CTTAGGGTTTCTAAGAGAGTACCAACCTCTTTTCATGGCACAAAAGACCAACACCATGCCTACCTTAAAACTGGCAGCTCTTAACTCCTTGTTAGCTGCC

Target sequence

TAGAAAAGGATACTCCAGGTCCACCTATATTTTTG

Reference

Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.