DTL _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016401
Fusion event
HBV-DTL integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1545
End
1580
Orient
+
Integrated sequence
ACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTG
Host Sequence
Chromosome
chr1
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
212250476/212077134 (Hg38)
End
212250511/212077169 (Hg38)
Orient
+
Location type
Intronic
Target gene
DTL
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-30a-5p ; hsa-mir-215-5p ; hsa-mir-26b-5p ; hsa-mir-24-3p ; hsa-mir-92a-3p ; hsa-mir-138-1-3p ; hsa-mir-374a-3p ; hsa-mir-8063
Nearest miRNA
hsa-mir-101-1/Upstream/2453624; hsa-mir-1182/Downstream/444;
Nearest TSS
ENST00000473358/Upstream/5060; ENST00000463791/Downstream/3200;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/41112, chr1-CpG: 181/Downstream/207456
Upstream sequence
tgcaggcttgcctttctctgtccatcctcagcaaaccaccagggcatccgtctaagacaggaagctctgatcaccttattttccagctgaaacccctcag
Downstream sequence
TCTCTCAGCCCCAACCTCCTTGCTCTTTTGAAACACACATGCTAATAATAGTTATGTGTGTTTGTACTCGTTATTGTGCTGATTAATTCCCATGGCCTAT
Target sequence
ATTCAGAGCCTCAGGAAAATGAAAAGAGAATAACT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate