Basic Information
VIS ID
TVIS10016402
Fusion event
HBV-PROX1-AS1 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2920
End
2955
Orient
-
Integrated sequence
AGCAAACACCGCAAATCCAGATTGGGACTTCAATCC
Host Sequence
Chromosome
chr1
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
214048090/213874747 (Hg38)
End
214048125/213874782 (Hg38)
Orient
-
Location type
Intronic
Target gene
PROX1-AS1
Nearest miRNA
hsa-mir-101-1/Upstream/1797062; hsa-mir-1182/Downstream/6243071;
Nearest TSS
ENST00000473358/Upstream/143331; ENST00000607726/Downstream/51872;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/485132, chr1-CpG: 42/Downstream/105089
Upstream sequence
GCATGCAAAATTCAGAATATAAAAAAATGCAGGGCCTGGTTGCCCACATACATTCCTCAGGTTAAGGTGGATTTAAAGATGCCCAACAGAACCCAATGAA
Downstream sequence
CATACACACATACTCCTTAAAGACCAAGACACTTATTCCCCTCCATTAGTTCATAGGTGAGTTcctttctggggattgccctaaactgaagacagcagcc
Target sequence
TGTTTACCATGATGTGTCACTCAGCCCTACACACA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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