VISDB - VIS Detail

Expression analysis of TCGA samples

Basic Information

VIS ID

TVIS10016410

Fusion event

HBV-INCENP integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Tumor

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2012

PubMed ID

22267523

Virus Sequence

Virus name

HBV

Reference genome

NC_003977

Start

1050

End

1085

Orient

-

Integrated sequence

CGTTGATGCCTTTGTATGCATGTATTCAATCTAAGC

Host Sequence

Chromosome

chr11

Cytoband

q12.3

Reference genome

GRCh37/hg19

Start

61918073/62150601 (Hg38)

End

61918108/62150636 (Hg38)

Orient

-

Location type

Intronic

Target gene

INCENP

miRNAs that regulate target gene

hsa-mir-142-3p ; hsa-mir-181a-5p ; hsa-mir-423-3p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-299-3p ; hsa-mir-181d-5p ; hsa-mir-548u ; hsa-mir-7161-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-4668-5p ; hsa-mir-3148 ; hsa-mir-219a-2-3p ; hsa-mir-219b-3p ; hsa-mir-554 ; hsa-mir-4756-3p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-135a-3p ; hsa-mir-3123 ; hsa-mir-9500 ; hsa-mir-182-5p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-mir-4536-5p ; hsa-mir-5681b ; hsa-mir-4470 ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-4657 ; hsa-mir-4491 ; hsa-mir-5683 ; hsa-mir-4428 ; hsa-mir-3919 ; hsa-mir-5003-5p ; hsa-mir-6822-5p ; hsa-mir-6750-5p ; hsa-mir-5584-5p ; hsa-mir-4282 ; hsa-mir-6770-3p ; hsa-mir-4467 ; hsa-mir-3622b-5p ; hsa-mir-6847-3p ; hsa-mir-24-2-5p ; hsa-mir-24-1-5p ; hsa-mir-216a-5p

Nearest miRNA

hsa-mir-129-2/Upstream/272323; hsa-let-7a-2/Downstream/416375;

Nearest TSS

ENST00000527297/Upstream/20042; ENST00000531099/Downstream/1846;

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/26528, chr11-CpG: 98/Downstream/186671

Upstream sequence

TCCGAACCTCTTTACTTTCCATTTTGGCGTCTTTTGGCAAGGTCACACTGAGTTTATACAGTGTACCTGTGTCTAGGTTCATGGCTTTCCAAGTATGCCA

Downstream sequence

CAGCTCGGGGAGGCAGGAAAGTCCTTGAGGAGTGCATGAGGCACTTGAGCAGGATCTGACCTGGAGTTTACAGGCCCCAGCATTAAACCAGAATGTGGGT

Target sequence

GGCAGAACACCAAGCTGGAGCCTGGGGCTTCCAGC

Reference

Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.