Basic Information
VIS ID
TVIS10016411
Fusion event
HBV-chr11 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
371
End
406
Orient
-
Integrated sequence
TCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCT
Host Sequence
Chromosome
chr11
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
64357205/64589733 (Hg38)
End
64357240/64589768 (Hg38)
Orient
-
Fragile sites / regions
FRA11H
Nearest miRNA
hsa-mir-1237/Upstream/221030; hsa-let-7a-2/Downstream/288755;
Nearest TSS
ENST00000527297/Upstream/22133; ENST00000336464/Downstream/873;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/21240, chr11-CpG: 73/Downstream/17578
Nearby gene
SLC22A12(+1077) ;
Upstream sequence
ACCAACCTAATGACTTGGATCTAAAATAAAAGTGTCTTCATTTTAAAAATTCTCAGAAAACTAGGCTTTAGTAAGCATAGAATACTATTAATTTATTAAT
Downstream sequence
CAAACACCTGGGTTGCCATCACTGCTGCACTGcacatatacgcatgcacacatgtacacacatgcacttgtgcaaacacatgtgcacacatacacagaca
Target sequence
CAAATGGAGAGTTTTATGCCCAAAGCTCATAAGAG
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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