Basic Information
VIS ID
TVIS10016416
Fusion event
HBV-chr11 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
683
End
718
Orient
-
Integrated sequence
AGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCC
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
115511377/115640659 (Hg38)
End
115511412/115640694 (Hg38)
Orient
-
Fragile sites / regions
FRA11G ; FRA11B
Nearest miRNA
hsa-mir-10392/Upstream/2190571; hsa-let-7a-2/Downstream/3003306;
Nearest TSS
ENST00000527297/Upstream/2096; ENST00000539305/Downstream/18964;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/135496, chr11-CpG: 46/Downstream/18585
Upstream sequence
ACTAGGCCCTTCCTTAGAGTCCCATCCAGCAGGGCTGAAGAGACTTGGACCTAAGTAAGCCACCTGGGGCAGAGGCAGAGCTAGAATGGGGAAGGGTTTA
Downstream sequence
CGTTAAATCTCCACTCTGCATCCTGAAAAGTAACTTCTGTGAAACTCTCCTTCCATCTCCTCATCAATTTCAGTCAGCTGTTTTTGTTTTCTCTTTTTCT
Target sequence
TTTGTATTTTGGGAGATGTATAGCAAGGAGAAAAT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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