Basic Information
VIS ID
TVIS10016417
Fusion event
HBV-chr11 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1520
End
1555
Orient
-
Integrated sequence
ACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCT
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
116986983/117116267 (Hg38)
End
116987018/117116302 (Hg38)
Orient
+
Fragile sites / regions
FRA11G ; FRA11B
Nearest miRNA
hsa-mir-10392/Upstream/3666179; hsa-let-7a-2/Downstream/1527698;
Nearest TSS
ENST00000527297/Upstream/17280; ENST00000533677/Downstream/27965;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/17471, chr11-CpG: 83/Downstream/27681
Nearby gene
SIK3(-18025) ; PAFAH1B2(+27981) ;
Upstream sequence
GCCCAGGGAGGCAAAGAAGTTGGCTTGGTAAGCCATGTGGAGGGGCAGCGGGAAGAGTCGGTGAAGCAAAAAGAAGCAGATGGGAGGGGCATTTATGCCT
Downstream sequence
GTGTCTGggccgggcatggtggctcacgcctgtaatcccagcactttgggaggccgaggcagatggatcacaaggtcaggagttcaaaaccagcctggcc
Target sequence
ctgtcacccaggctggagtgcagGCCTCTTAAAAA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate