Basic Information
VIS ID
TVIS10016419
Fusion event
HBV-chr12 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
13
End
48
Orient
+
Integrated sequence
TCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCC
Host Sequence
Chromosome
chr12
Cytoband
p13.2
Reference genome
End
11740616/11587682 (Hg38)
Orient
+
Nearest miRNA
hsa-mir-1244-3/Upstream/2348096; hsa-let-7i/Downstream/524270;
Nearby gene
LINC01252(-23281) ; ETV6(+62171) ;
Nearest cancer related gene
ETV6(OG, +62171) ;
Upstream sequence
AAAATGTAATGCCCTGTTCCTAGGGATAATAAGAATCACTGTGTCAGCTCCTTGTTACTTCCACCACATGGCTTTGCTAGTTTCCAAATGAAGAGGTTCC
Downstream sequence
CCAAACTTAAAACTTTTCTTTTTTCACCCATGCTTCCCCTTGCCCTGACCAGATAGGAAAAGATTTAATCAGTTGCCAAATTCTGTGGCTTCTTCCTCAT
Target sequence
AATGAGCCATGTTGGGTTTTCATCATTTACAAAGT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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