Fusion event
HBV-chr12 integration
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
TCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCC
End
11740616/11587682 (Hg38)
Nearest miRNA
hsa-mir-1244-3/Upstream/2348096; hsa-let-7i/Downstream/524270;
Nearest cancer related gene
Upstream sequence
AAAATGTAATGCCCTGTTCCTAGGGATAATAAGAATCACTGTGTCAGCTCCTTGTTACTTCCACCACATGGCTTTGCTAGTTTCCAAATGAAGAGGTTCC
Downstream sequence
CCAAACTTAAAACTTTTCTTTTTTCACCCATGCTTCCCCTTGCCCTGACCAGATAGGAAAAGATTTAATCAGTTGCCAAATTCTGTGGCTTCTTCCTCAT
Target sequence
AATGAGCCATGTTGGGTTTTCATCATTTACAAAGT
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.