KSR2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016424
Fusion event
HBV-KSR2 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1469
End
1504
Orient
+
Integrated sequence
GGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTG
Host Sequence
Chromosome
chr12
Cytoband
q24.23
Reference genome
GRCh37/hg19
Start
118260607/117822802 (Hg38)
End
118260642/117822837 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E ; FRA12C
Target gene
KSR2
miRNAs that regulate target gene
hsa-mir-940 ; hsa-mir-7847-3p ; hsa-mir-6894-5p ; hsa-mir-765 ; hsa-mir-7154-3p ; hsa-mir-4751 ; hsa-mir-766-5p ; hsa-mir-139-5p ; hsa-mir-3922-5p ; hsa-mir-5582-5p ; hsa-mir-2113 ; hsa-mir-218-5p ; hsa-mir-7106-3p ; hsa-mir-361-3p ; hsa-mir-6793-3p ; hsa-mir-483-3p ; hsa-mir-4700-3p ; hsa-mir-642a-5p ; hsa-mir-1236-3p ; hsa-mir-4469 ; hsa-mir-6515-3p ; hsa-mir-2276-5p ; hsa-mir-5188 ; hsa-mir-1243 ; hsa-mir-3654 ; hsa-mir-6892-3p ; hsa-mir-4732-5p ; hsa-mir-6832-5p ; hsa-mir-7107-3p ; hsa-mir-6753-3p ; hsa-mir-20b-3p ; hsa-mir-3137 ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-6739-3p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-607 ; hsa-mir-511-5p ; hsa-mir-6888-3p ; hsa-mir-6715b-3p ; hsa-mir-6830-3p ; hsa-mir-3120-5p ; hsa-mir-4732-3p ; hsa-mir-6732-3p ; hsa-mir-6715a-3p ; hsa-mir-1324
Nearest miRNA
hsa-let-7i/Upstream/1394484; hsa-mir-1178/Downstream/1890797;
Nearest TSS
ENST00000382841/Upstream/145551; ENST00000544667/Downstream/66617;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/61320, chr12-CpG: 49/Downstream/146220
Nearby gene
NOS1(-461000) ; RFC5(+193900) ;
Nearest cancer related gene
KSR2(OG, No orient, 0)
Upstream sequence
AAACATTCAAGGAGTAATTTCAAAATTTTGCATATTCATATTAAGTTCTGAATCCAATTATAAATAATTGCTTAAATATACTAGAGAAAAGAAACTTGAG
Downstream sequence
tcatgaagtagaaaaatcctaagttgacagtcagggaccgtctgtgtgtgattaaaaactgggacatgtactaccaagaaaaagaaaagggttatcccaa
Target sequence
acattgtctcctggatgtgtattgccttcacacca
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate