Basic Information
VIS ID
TVIS10016425
Fusion event
HBV-chr12 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
357
End
392
Orient
+
Integrated sequence
ACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGT
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
129194470/128709925 (Hg38)
End
129194505/128709960 (Hg38)
Orient
+
Fragile sites / regions
FRA12E
Nearest miRNA
hsa-let-7i/Upstream/415747; hsa-mir-6763/Downstream/3872037;
Nearest TSS
ENST00000382841/Upstream/442522; ENST00000611714/Downstream/91741;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/4483, chr12-CpG: 17/Downstream/85751
Nearby gene
TMEM132C(-2010) ;
Upstream sequence
CACAGGAATATGTTTTTCTGTTCAAACTGGCACAGAGGTCATTAATTTCTAATCTACATAATTTAATTTTGCAACTATCATATTGAATATATAACATCAA
Downstream sequence
atcaaagCTGCAGGAGACCTCGGCCTCCTCAGCACACGGTTGCAGGTTCGCAGTGAGAGAGGACAGAGGCTTCAAGACCTTTCCTTTAGATACCACATCT
Target sequence
gaagcagatgagaggaatatattgtgattttccta
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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