Basic Information
VIS ID
TVIS10016430
Fusion event
HBV-LOC105370324 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
117
End
152
Orient
-
Integrated sequence
TCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTG
Host Sequence
Chromosome
chr13
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
98347349/97695095 (Hg38)
End
98347384/97695130 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13D
Target gene
LOC105370324
Nearest miRNA
hsa-mir-1297/Upstream/1267803; hsa-mir-1267/Downstream/513394;
Nearest TSS
ENST00000623511/Upstream/17132; ENST00000604129/Downstream/244226;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/260230, chr13-CpG: 133/Downstream/280675
Nearby gene
RAP2A(-227097) ; IPO5(+258579) ;
Upstream sequence
tcttagccaggatggtctccatctcctgacctcgtgatccacctgccttggcctcccaaaatgctgggattacaggagtgagccactgcacccagccAGT
Downstream sequence
CAGCAAGGTGCCtttatttcttttttaggcaggatgtcacactgtcacccaacctggagtactttggcgcgatctctgctcactgcagcctcaacctccc
Target sequence
TTGCATCAAGTCTTTCAGTATCGGCTTTTGGAGTG
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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