Basic Information
VIS ID
TVIS10016435
Fusion event
HBV-chr14 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2504
End
2539
Orient
-
Integrated sequence
CTGTACCTGTCTTTAATCCTCATTGGAAAACACCAT
Host Sequence
Chromosome
chr14
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
38338112/37868907 (Hg38)
End
38338147/37868942 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-208a/Upstream/916516; hsa-mir-1185-1/Downstream/9892053;
Nearest TSS
ENST00000550708/Upstream/41606; ENST00000553887/Downstream/33182;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/245936, chr14-CpG: 43/Downstream/339007
Upstream sequence
AAAGCATGAAAGAGAATTCACTGTCCAGATTTGTTGATTAGTATCATGAGTAGTGGAATCTGAGCGTTCTTGGGGACTGAGAAAGCAGTGGGAATAGATG
Downstream sequence
ggttgacagagttggaggctactactctctccagtaaatgacaactaactcgTATGGCCAATTGAAAGTTGGAAAGTACTACAAACAGTCTATGTGTTCA
Target sequence
aagttatgcaagcacagagctaaggtttgaatgtg
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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