Basic Information
VIS ID
TVIS10016438
Fusion event
HBV-chr15 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2753
End
2788
Orient
-
Integrated sequence
ACACTCTATGGAAGGCGGGTATATTATATAAGAGAG
Host Sequence
Chromosome
chr15
Cytoband
q23
Reference genome
GRCh37/hg19
Start
67739491/67447153 (Hg38)
End
67739526/67447188 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA15A
Target gene
IQCH ; IQCH-AS1
Nearest miRNA
hsa-mir-10393/Upstream/950119; hsa-mir-11181/Downstream/1354662;
Nearest TSS
ENST00000557528/Upstream/33615; ENST00000558759/Downstream/42827;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/192081, chr15-CpG: 95/Downstream/73844
Upstream sequence
aaagttgacaaacccttaggcagcctagaaagaaaaacagagaaaatcaaaccgaaagctggttcttagaaaaagtcaataaagttgacacacccttagg
Downstream sequence
ttcggaggatgatatgagcaaataccacagtgccttgcacttaataggcccttaatCTACATCAGTGTCCCTTCCTCTTTCCTTTCCCAAGTCTCCCTCC
Target sequence
aaaatgggagtatgaataccaaacccataaagttg
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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