Basic Information
VIS ID
TVIS10016447
Fusion event
HBV-LOC101927837 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1619
End
1654
Orient
+
Integrated sequence
CCGTGAACGCCCACCAAATATTGCCCAAGGTCTTAC
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
67525517/67491614 (Hg38)
End
67525552/67491649 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA16B
Target gene
LOC101927837
Nearest miRNA
hsa-mir-1225/Upstream/289219; hsa-mir-11401/Downstream/741777;
Nearest TSS
ENST00000527434/Upstream/7372; ENST00000562116/Downstream/26769;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/10172, chr16-CpG: 92/Downstream/37023
Nearby gene
AGRP(-7836) ; RIPOR1(+37164) ;
Upstream sequence
ctcataaggctcttgagaggatgaaatgaatccatttgcaaaaaaggaccagagcaacttggaacacataagcactcggtatgtgtcagctgttattaac
Downstream sequence
TGTCGGTTTCCCACTTCCAGGGTAACTGGATGGAATTTCTGCCTTCATGGTGGTTCAAGCCTGAAGTGCCTTGAGACCAGAAGTAAAGAGTTCCTTCCTC
Target sequence
TTTACATGTCTAGCTTCAAAAAATGCCATGCAGGT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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