Basic Information
VIS ID
TVIS10016454
Fusion event
HBV-chr17 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1950
End
1985
Orient
-
Integrated sequence
TCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGA
Host Sequence
Chromosome
chr17
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
74998686/77002604 (Hg38)
End
74998721/77002639 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-10226/Upstream/266056; hsa-mir-1250/Downstream/86778;
Nearest TSS
ENST00000595228/Upstream/44382; ENST00000568056/Downstream/84077;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/33383, chr17-CpG: 41/Downstream/53225
Upstream sequence
cctttattttattttactttttgtagatacagggtctccctatgttatccagacaggtctcaaattcctgacctcaaccatcctcacatctcggcctccc
Downstream sequence
CTGACGGCAGGCCCTTTCCAGGCAAGCTGCCAAGTGCTGGCCCCTGTAACGTGTTCAGCTGAGGATTCATCCCAGGCCAGGAATATGGGTGCAAGAGAGT
Target sequence
taCAACGGTCCTCAGCCCTGGTGCCCAGCACCCCA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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